1937年加拿大报告了金属工因接触高浓度镉烟而引起呼吸道损害的事故,损害呈急性且严重,死亡率高,肺有充血和水肿征象。在其后另一事故中有少数存活者肺功能部份恢复,但以后死于慢性肺功能不足。一些从急性接触中存活下来的病例似有严重而广泛的小叶中心性肺气肿。 In 1937, Canada reported that metal workers caused respiratory tract damage due to exposure to high concentrations of cadmium smoke, with acute and severe damage, high mortality and signs of congestion and edema in the lungs. In a subsequent incident, a minority of survivors recovered partly from lung function but subsequently died of chronic lung insufficiency. Some cases of survival from acute exposure seem to have severe and extensive lobulated central emphysema.