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目的探讨各种类型病毒性肝炎患者血清一氧化氮（ＮＯ）变化及其临床意义。方法应用紫外分光光度计比色法测定血清ＮＯ含量。结果所有类型病毒性肝炎患者血清ＮＯ水平均较正常人高。急性肝炎患者血清ＮＯ水平与感染病原型无关，与血清ＡＬＴ及ＴＢｉｌ无明显相关。慢性肝炎，肝炎后肝硬化，重症肝炎中、晚期患者血清ＮＯ水平显著增高。且与血清ＡＬＴ、ＴＢｉｌ值呈正相关，与ＰＬＤ、ＬＨ、ＰＣⅢ水平呈正相关。与凝血酶原活动度（ＰＴＡ）及血清白蛋白（ＡＬＢ）呈负相关。结论急性肝炎时，ＮＯ轻度升高，是体对炎症的应答应反，此时发挥对肝细胞的保护作用。慢性肝炎、肝硬化及重症肝炎患者血清ＮＯ水平明显增高，表现对肝细胞的损伤作用，参与肝纤维化过程。ＮＯ是重症肝炎及肝硬化高动力循环的成因。
Objective To investigate the changes of serum nitric oxide (NO) in patients with various types of viral hepatitis and its clinical significance. Methods The content of serum NO was measured by UV spectrophotometer. Results All patients with viral hepatitis had higher serum NO levels than normal controls. Serum NO levels in patients with acute hepatitis have nothing to do with the infection of pathogens, and serum ALT and TBil no significant correlation. Chronic hepatitis, cirrhosis of hepatitis, severe hepatitis, serum NO levels were significantly higher in patients with advanced disease. The serum ALT and TBil levels were positively correlated with PLD, LH and PCⅢ levels. And prothrombin activity (PTA) and serum albumin (ALB) was negatively correlated. Conclusions In acute hepatitis, NO is slightly elevated, and the response of body to inflammation should be reversed. At this time, the protective effect on hepatocytes is exerted. Serum levels of NO in patients with chronic hepatitis, cirrhosis and severe hepatitis were significantly higher than those in patients with chronic hepatitis, indicating the damage of liver cells and the involvement of liver fibrosis. NO is a cause of severe hepatitis and cirrhosis hyperdynamic circulation.