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资料来源:www.pharmacist.com 发布日期:2010.7.8来自GENDEP(基于基因组学的抗抑郁药物治疗)研究项目中的706名从轻度到重度抑郁的患者的基因型分析数据表明,UST基因(糖醛基2-磺基转移酶)的rs2500535位点的多态性与去甲替林的临床疗效有显著的遗传学关联;暗示IL11基因(白介素-11)与依他普仑的临床疗效有关联;但尚需要更多的遗传学研究去证实上述的发现。GENDEP的研究项目是一项为期12周,半随机,标签公开的试验研究,其评估了患者的基因和对抗抑郁药
Source: www.pharmacist.com Publish Date: July 7, 2010 Genotypic data from 706 patients with mild to severe depression in the GENDEP (Genomics-Based Antidepressant Therapy) research project indicate that the UST gene ( There was a significant genetic relationship between the polymorphism of rs2500535 in the glycosyl-2-sulfotransferase and the clinical efficacy of nortriptyline. The clinical efficacy of IL11 gene (interleukin-11) and escitalopram was associated with However, more genetic studies are needed to confirm the above findings. GENDEP’s research project is a 12-week, semi-randomized, open-label pilot study that evaluated patients’ genes and antidepressants