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目的研究共聚物2-甲基丙烯酸二甲胺乙酯-co-二烯丙基二甲基氯化铵水凝胶对中草药notoginsenoside为模型药物的调控给药释放效应。方法以辐射共聚和交联法合成的新颖温度/酸度敏感性水溶胶,注入3只大鼠体内以研究中药notoginsenoside在其体内受控释放性能。共聚物结构和凝胶片断经红外、紫外以及释放药效分析确证。结果2-甲基丙烯酸二甲胺乙酯(DMAEMA)和二烯丙基二甲基氯化铵(DADMAC)为共沸化合物。在标题聚合物中,聚DADMAC电解质的电荷能沿大分子链均匀分布。凝胶的平衡溶胀度(EDS)在载体电荷密度3 %摩尔时最大,而载体电荷密度接近5 %摩尔及其以上时温度敏感性消失。溶液温度、酸度和盐浓度以及凝胶组成和结构能调控notoginsenoside给药释放;用三七(Panax notoginsen,PANS)饱和的水凝胶能有效释放notoginsenoside而呈现出相当好的生物兼容性和具有愈合大鼠伤口的功能。结论靶向药物释放可以通过调节pH,离子强度,溶液温度以及凝胶的组成和结构而有效实现。
Aim To study the release effect of copolymer 2-dimethylaminoethylmethacrylate-co-diallyldimethylammonium chloride hydrogel on the modulation of drug delivery by Chinese herbal medicine notoginsenoside as a model drug. Methods A novel temperature / pH-sensitive hydrogel synthesized by radiation copolymerization and cross-linking was injected into three rats to study the controlled release of Chinese traditional medicine notoginsenoside in vivo. Copolymer structure and gel fragments were confirmed by infrared, ultraviolet and release pharmacodynamics. Results Dimethylaminoethyl methacrylate (DMAEMA) and diallyldimethylammonium chloride (DADMAC) are azeotropic compounds. In the title polymer, the charge of the poly DADMAC electrolyte can be distributed evenly along the macromolecular chains. The equilibrium swelling degree (EDS) of the gel is the largest at a charge density of 3% of the carrier, and the temperature sensitivity disappears when the charge density of the carrier is close to 5% by mole or more. Solution temperature, acidity and salt concentration, as well as the gel composition and structure, can regulate the release of notoginsenoside. The hydrogel saturated with Panax notoginsen (PANS) can effectively release notoginsenoside while showing good biocompatibility and healing Wound function in rats. Conclusion Targeted drug release can be effectively achieved by adjusting pH, ionic strength, solution temperature and the composition and structure of the gel.