论文部分内容阅读
在６只清醒、可活动的猕猴上观察了大脑皮层体感Ｉ区（ＳＩ区）皮层内注射微量氯化钙对外周皮肤痛阂和针刺镇痛的影响。结果：①ＳＩ区皮层内注射１８２ｍｍｏｌ／Ｌ氯化钙５μｌ，对侧肢体皮肤痛闽由０．６３±０．０３ｍＡ增高至１．０８±０．０７ｍＡ，ｐ＜０．００１。②针刺足三里穴，痛阂明显升高（Ｐ＜０．０１），由０．５５±０．０４ｍＡ升高至１．２２±０．０６ｍＡ，而针刺穴位井同时皮层内注射氯化钙时，痛阂进一步增高至１．４４±０．１ｍＡ。同时针刺穴位及皮层内注射氯化钙与单纯针刺穴位时痛阂变化比较ｐ＜０．０５。③每只实验猴皮层内注射相同容量生理盐水，均未见痛阈发生明显变化（Ｐ＞０．０５）。结果表明：皮层内注射氯化钙可使外周皮肤痛阈明显升高并加强针刺镇痛效应。提示皮层内钙离子参与ＳＩ区皮层对外周皮肤痛觉及针刺镇痛的调制。
The effect of intracortical injection of trace calcium chloride on peripheral dermal dysfunction and acupuncture analgesia was observed on six conscious, movable macaques. Results: ① In the SI area, 5μl of 182mmol / L calcium chloride was injected into the cortex of the SI area, and the skin pain of the contralateral limb increased from 0.63 ± 0.03mA to 1.08 ± 0.07mA, p <0.001. (2) Acupuncture at Zusanli acupoint increased the pain threshold (P <0.01) from 0.55 ± 0.04mA to 1.22 ± 0.06mA, while the acupuncture acupoint also cortical injection of chloride Calcium, pain threshold further increased to 1.44 ± 0.1mA. At the same time acupuncture points and cortical injection of calcium chloride and acupuncture points when compared pain threshold changes p <0.05. (3) There was no obvious change of pain threshold (P> 0.05) in each experimental cortex injection of the same volume of saline. The results showed that intracortical injection of calcium chloride significantly increased the pain threshold of peripheral skin and acupuncture analgesia. Suggesting that intracellular cortical calcium ion involved in SI cortical skin pain and acupuncture analgesia modulation.