论文部分内容阅读
目的：探讨度洛西汀联合替勃龙治疗女性更年期抑郁症的疗效和安全性。方法选择2011年9月-2013年9月我院精神科收治的女性更年期抑郁症患者70例，随机分为治疗组与对照组各35例。对照组予度洛西汀肠溶片，治疗组在对照组治疗基础上给予替勃龙片。治疗6周用 HAMD，HAMA，TESS 量表评定疗效和不良反应。结果治疗组显效率85.7%，总有效率94.3%明显高于对照组的65.7%及80.0%，差异有统计学意义（ P ＜0.05）。治疗1、2、4、6周后2组 HAMD 及 HAMA 评分均较治疗前及上一计分段明显降低，且治疗组评分降低程度较对照组更为明显，差异均有统计学意义（P ＜0.05）。2组常见不良反应发生率比较差异无统计学意义（P ＞0.05），患者均能耐受或经对症治疗缓解，未对治疗产生影响。结论度洛西汀联合替勃龙治疗女性更年期抑郁症的疗效优于单用度洛西汀且耐受性好。值得临床推广应用。“,”Objective To discuss the efficacy and safety of duloxetine combinate with tibolone in the treatment of fe-male climacteric depression. Methods From September 2011 to September 2013,70 cases of female patients with climacteric depression were selected,and then randomly divided into treatment group and control group,each of 35 cases. The control group received duloxetine for treatment. The treatment group was added tibolone based on the control group. After treatment for 6 weeks,the efficacy and safety were evaluated with HAMD,HAMA and TESS scale. Results The effective rate and total effec-tive rate was 85. 7% ,94. 3% respectively in the treatment group,which was obviously higher than 65. 7% ,80% in control group,the differences were statistically significant(P < 0. 05). After treatment for 1,2,4,6 weeks,the HAMD and HAMA scale of 2 groups decreased significantly compared with before treatment and the previous subsection,and the score decreased obviously in the treatment group compared with the control group,the differences were statistically significant(P 0. 05). The patients were all tolerated or relieved by symptomatic treatment. Conclusion The efficacy of duloxetine combinate with tibolone was better in the treatment of female climacteric depression than duloxetine alone,and with good tolerance,which is worthy of clini-cal application.