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丙泊酚 ( ｐｒｏｐｏｆｏｌ)是一种速效、短效的静脉麻醉药 ,近年临床上应用广泛 ,但对细胞遗传毒性评价的研究报道甚少。本文采用Ａｍｅｓ试验从分子水平对丙泊酚进行遗传毒性测定。材料与方法Ａｍｅｓ试验 选用平板掺入法 ,试验采用ＴＡ98、ＴＡ10 0、ＴＡ97、ＴＡ10 2四个
Propofol (propofol) is a fast-acting and short-acting intravenous anesthetic. It has been widely used clinically in recent years, but little is known about the evaluation of cytotoxicity. In this paper, Ames test was used to determine genotoxicity of propofol at molecular level. Materials and methods Ames test selected plate incorporation method, the test using TA98, TA10 0, TA97, TA10 2 four