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目的对儿童溃疡性结肠炎(UC)患者进行检测血清中C反应蛋白(CRP)水平,并分析CRP与UC患儿的临床疗效和预后之间的关系。方法收集25例活动期UC患儿、14例缓解期UC患儿及32例健康儿童血清标本,检测CRP水平,研究CRP与UC疾病活动程度的关系。对UC患儿进行有效治疗,进一步观察CRP与临床治疗效果和预后的相关性。结果活动期UC患儿血清CRP水平比缓解期患儿及正常儿童明显升高,差异有统计学意义(P<0.001)。活动性UC患儿经有效治疗后,病情缓解,血清中CRP水平显著下降(P<0.001),接近缓解期UC患儿和健康者。结论 CRP在活动性UC患儿血清中显著升高,并能判断疾病的预后转归。
Objective To detect the level of serum C-reactive protein (CRP) in children with ulcerative colitis (UC) and to analyze the relationship between the clinical efficacy and prognosis of CRP and UC. Methods Serum samples were collected from 25 active UC patients, 14 remission UC patients and 32 healthy children. The levels of CRP were measured and the relationship between CRP and the activity of UC was studied. Effective treatment of children with UC, and further observation of CRP and clinical outcomes and prognosis of the correlation. Results The serum CRP level of active UC patients was significantly higher than that of children with remission and normal children (P <0.001). Active treatment of children with effective treatment of UC, the disease remission, serum CRP levels decreased significantly (P <0.001), close to the remission of UC children and healthy subjects. Conclusion CRP is significantly elevated in sera of patients with active UC and can predict the prognosis of the disease.