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目的 探讨大鼠脑缺血再灌注后血脑屏障 (BBB)通透性的改变以及转移生长因子 β1 (TGF β1 )在脑组织中的表达。方法 采用线栓法制备大鼠局灶脑缺血再灌注模型 ,通过测定脑组织中伊文氏蓝 (EB)含量及免疫组化法来观察TGF β1 的表达。结果 缺血 2h再灌注 3h ,BBB通透性开始增
Objective To investigate the changes of permeability of the blood-brain barrier (BBB) and the expression of transforming growth factor-β1 (TGF-β1) in brain after cerebral ischemia-reperfusion in rats. Methods Focal cerebral ischemia-reperfusion model was established by thread occlusion method. The expression of TGF-β1 was observed by measuring the content of Evans blue (EB) in brain tissue and immunohistochemistry. Results 2h ischemia reperfusion 3h, BBB permeability began to increase