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多黏菌素通常是唯一对多重耐药(MDR)革兰阴性菌有效的药物。临床上可选用的多黏菌素类有多黏菌素B和多黏菌素E。可能由于多黏菌素E具有较好的安全性,临床上应用更广泛。但文献中对这2种多黏菌素类的肾毒性发生率的报道很不一致。本研究旨在比较多黏菌素B和多黏菌素E的肾毒性及患者使用后发生肾毒性的独立危险因素。在两组哺乳动物的肾脏细胞系比较多黏菌素B和多黏菌素E的细胞毒性。结果表明,两者的细胞毒性无显著差异。
Polymyxin is usually the only drug that is effective against multi-drug resistant (MDR) gram-negative bacteria. Polymyxins clinically available polymyxin B and polymyxin B. Polymyxin E may be due to better safety, clinical application more widely. However, the literature on the incidence of these two kinds of polymyxin nephrotoxicity is very inconsistent. This study aimed to compare the nephrotoxicity of polymyxin B with polymyxin E and the independent risk factors for developing nephrotoxicity in patients. The cytotoxicity of polymyxin B and polymyxin E were compared in two groups of mammalian kidney cell lines. The results show that there is no significant difference between the two cytotoxicity.