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目的:检测Ki67、Fas、Bax及Survivin蛋白在人体大、小肝癌组织中的表达及其与肝癌生物学行为的关系。方法:应用免疫组化方法检测40例小肝癌和43例大肝癌中Ki67、Fas、Bax及Survivin蛋白的表达,结合临床病理资料分析。结果:Fas及Bax在小肝癌中的表达显著高于大肝癌(P<0.05);Survivin与Ki67的表达均与Fas表达呈显著负相关(P<0.05),与包膜侵犯、癌栓形成及肿瘤转移呈显著正相关(P<0.01);Fas的表达与癌栓形成及肿瘤转移呈显著负相关(P<0.01)。结论:伴随Fas及Bax的表达减少或缺失,肝癌细胞凋亡的趋势逐渐减弱,从而导致肿瘤迅速生长、增大。Ki67、Fas与Survivin的表达与肝癌的生物学行为密切相关。
Objective: To detect the expression of Ki67, Fas, Bax and Survivin protein in human large and small hepatocellular carcinoma tissues and their relationship with biological behavior of hepatocellular carcinoma. Methods: Immunohistochemistry was used to detect the expression of Ki67, Fas, Bax and Survivin protein in 40 cases of small hepatocellular carcinoma and 43 cases of large hepatocellular carcinoma. Results: The expression of Fas and Bax in small hepatocellular carcinoma was significantly higher than that of large hepatocellular carcinoma (P<0.05). The expression of survivin and Ki67 was significantly negatively correlated with the expression of Fas (P<0.05), and was associated with capsule invasion, tumor thrombus formation, and Tumor metastasis was significantly positively correlated (P<0.01); Fas expression was significantly negatively correlated with tumor thrombus formation and tumor metastasis (P<0.01). Conclusion: With the decrease or absence of Fas and Bax expression, the apoptosis of hepatoma cells gradually weakens, leading to the rapid growth and increase of tumors. The expression of Ki67, Fas and Survivin is closely related to the biological behavior of liver cancer.