虽有因靶细胞的类固醇激素受体异常而对各种类固醇激素产生耐受性,并认为是遗传因子异常所致的报道,但对类固醇激素过敏的报道尚未见到。本文作者曾见过一例特征似柯兴氏综合征的临床表现,而对皮质醇过敏者。今进行报道,并由此提出了皮质醇过敏综合征这一新概念。其病因在于细胞对糖皮质激素反应亢进。患者男、55岁、糖尿病多年,并患有白细胞增多症。呈满月貌、水牛背、向心性肥胖。血压正常。白细胞15000个/mm~3,中性粒细胞82％、空腹血糖180mg/dl、HbAIc9.1％、内分泌学检查,早晨8时血清总皮质醇为0.8±0.7μg/dl(正常值5～10)、游离皮 Although the abnormality of the target cells due to steroid hormone receptors on various steroid hormone tolerance, and is considered genetic abnormalities caused by the report, but the report of steroid hormone allergy has not yet been seen. The authors of this article have seen one case of a clinical feature that is characteristic of Cushing’s syndrome and is allergic to cortisol. Now reported, and thus proposed a new concept of cortisol allergy syndrome. The etiology is that cells respond to glucocorticoid hyperactivity. Male, 55 years old, with diabetes for many years and with leukocytosis. Full moon appearance, buffalo back, concentric obesity. Normal blood pressure. Leukocyte 15000 / mm ~ 3, neutrophil 82%, fasting blood glucose 180mg / dl, HbAIc9.1%, endocrinological examination, 8:00 am serum total cortisol 0.8 ± 0.7μg / dl (normal 5 ~ 10 ), Free skin