褪黑素（ＭＴ）是一种主要由松果腺分泌的神经内分泌激素，近年来，它的抗氧化清除自由基能力和神经内分泌免疫调节功能倍受关注［１］。但有关ＭＴ对阿霉素肾病（ＡＩＮ）干预作用的报道较少。我们在ＡＩＮ 和松果腺摘除（ＰＸ ）模型基础上，观察ＭＴ对ＡＩＮ大鼠血尿生化指 Melatonin (MT), a neuroendocrine hormone secreted mainly by the pineal gland, has gained much attention in recent years for its antioxidant capacity to scavenge free radicals and its neuroendocrine immune regulatory function [1]. However, there are few reports about the effect of MT on adriamycin nephropathy (AIN). On the basis of AIN and pineal gland removal (PX) model, we observed the effect of MT on the biochemical index