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爱泼斯坦-巴尔病毒(EBV)是具有致瘤潜能的疱疹病毒,与多种恶性肿瘤的发生相关。近年来,对EBV潜伏感染膜蛋白1(LMP1)的结构、功能及其介导的信号转导通路的研究取得了显著进展。作者就LMP1通过核因子-κB(NF-κB)、活化蛋白1(AP-1)、双面联胎激酶(JAK)/信号转导和转录激活子(STAT)、Ets1、丝裂原激活的蛋白激酶(MAPK)/激活转录因子2(ATF2)途径和细胞周期依赖性激酶(Cdk)途径等,对细胞的生长、增殖、转化、分化、运动和凋亡的调控作一综述。
Epstein-Barr virus (EBV) is a herpes simplex virus that has oncogenic potential and is associated with a variety of malignancies. In recent years, significant progress has been made in the study of the structure, function and the signal transduction pathways of the latent membrane protein 1 (EBV) that is infected by EBV. The authors report on the role of LMP1 in activation of mitogen-activated protein kinase (LMP1) by nuclear factor-κB, AP-1, JAK / STAT, (MAPK) / Activating Transcription Factor 2 (ATF2) pathway and the cell cycle dependent kinase (Cdk) pathway, we review the regulation of cell growth, proliferation, transformation, differentiation, motor and apoptosis.