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多孔动物门(海绵) 已知海绵约有5000余种,人们早就推测它能产生抗生素。事实上,海绵的形态特征,加之不具备充分的物理性防御手段,故人们认为此种极其原始的生物必定具有化学性防御机制。 Bergman于1951年自海绵Cryptothetya crypta中分离出Epongotimidine(22)及Epongouridine,以此两种核苷为化学模板合成了具有抗肿瘤及抗病毒活性的抗生素Ara-C(D.araabinosyl citosine)及Ara-A(D.arabinosyl adenine),Ara-C具有强烈的抑制白血病作用,已用于临床治疗白血病,其治愈率超过50%。Ara-A(原文误为Ara-
Porous door (sponge) Known sponge about 5000 species, it has long been speculated that it can produce antibiotics. In fact, the sponge morphological characteristics, combined with the lack of adequate physical defense means that it is believed that this extremely primitive organism must have a chemical defense mechanism. Bergman isolated Epongotimidine (22) and Epongouridine from sponge Cryptothetya crypta in 1951. The two nucleosides were used as chemical templates to synthesize anti-tumor and antiviral antibiotics Ara-C (D.araabinosyl citosine) and Ara- A (Ararabinosyl adenine), Ara-C has a strong inhibitory effect on leukemia, has been used in the clinical treatment of leukemia, the cure rate of more than 50%. Ara-A (Original error was Ara-