【摘 要】
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目的探讨血浆肿瘤坏死因子α(TNF-α)在急性脑血管病发病过程中参与的病理生理过程。方法124例脑梗死或脑出血患者(ACVD组),112例门诊体检健康者(对照组),按ELISα法测定其TN
【机 构】
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河南省周口市第二人民医院,河南省周口市第二人民医院 46000周口市,46000周口市
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目的探讨血浆肿瘤坏死因子α(TNF-α)在急性脑血管病发病过程中参与的病理生理过程。方法124例脑梗死或脑出血患者(ACVD组),112例门诊体检健康者(对照组),按ELISα法测定其TNF-d浓度。结果ACVD急性期浓度显著高于对照组,恢复期TNF-α虽有下降,但仍高于正常组(P<0.01),且重型组的TNF-α浓度显著高于中轻型组(P<0.01)。结论TNF-α浓度与病情、病期呈现正相关关系,可作为判断病情、病期、用药及预后的一个指标。
Objective To investigate the pathophysiological process of plasma tumor necrosis factor-α (TNF-α) involved in the pathogenesis of acute cerebrovascular disease. Methods 124 patients with cerebral infarction or intracerebral hemorrhage (ACVD group) and 112 healthy subjects (control group) were enrolled in this study. The concentration of TNF-α was measured by ELISα method. Results The acute phase of ACVD was significantly higher than that of the control group. The level of TNF-α in convalescent phase was still lower than that of the normal group (P <0.01) ). Conclusion The concentration of TNF-α has a positive correlation with disease and disease stage, which can be used as an index to judge the condition, disease duration, medication and prognosis.
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