Prethrombotic status(PS) is a pathological process of imbalance of hemostasis and blood coagulation system caused by multiple factors easily causes hematological changes of thrombosis .A large amount of experiments and clinical researched have shown that thrombosis occurs under the comprehensive effect of changes of endothelia of blood vessel, platelets, blood coagulation and fibrolytic system.There have been many changes in these factors before thrombosis occurs.The later advance of experimental and clinical research of prethrombotic status was presented in this paper.