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目的:探讨不同病情程度的脓毒症患者降钙素原(PCT)、抗凝血酶Ⅲ(AT-Ⅲ)及D-二聚体(DD)含量的变化,为临床治疗和评价脓毒症预后提供依据。方法:选取重症医学科收治患者123例,其中非脓毒症37例,脓毒症患者86例,对入选病例进行PCT、AT-Ⅲ及DD含量检测。结果:脓毒症患者PCT、DD含量显著高于非脓毒症患者(P<0.01),随着病情的加重程度而升高;脓毒症患者AT-Ⅲ活性明显降低(P<0.01),随病情严重程度的增加逐渐降低。死亡组PCT、DD含量高于存活组(P<0.01),AT-Ⅲ活性低于存活组(P<0.01)。结论:检测脓毒症患者PCT、AT-Ⅲ及DD对病情严重程度的评估和预后判断有一定的临床意义。
Objective: To investigate the changes of procalcitonin (PCT), antithrombin Ⅲ (AT-Ⅲ) and D-dimer (DD) in patients with sepsis with different severity of illness, Prognosis provide the basis. Methods: A total of 123 patients admitted to the Department of Critical Care Medicine were enrolled. Among them, 37 were non-sepsis and 86 were sepsis. The PCT, AT-Ⅲ and DD contents were measured in selected cases. Results: The levels of PCT and DD in patients with sepsis were significantly higher than those without sepsis (P <0.01), and increased with the severity of sepsis. The activity of AT-Ⅲ in patients with sepsis was significantly lower (P <0.01) With the increase of the severity of the disease gradually decreased. The levels of PCT and DD in the death group were higher than those in the surviving group (P <0.01), while those in the surviving group were lower than those in the surviving group (P <0.01). Conclusion: The detection of PCT, AT-Ⅲ and DD in patients with sepsis have certain clinical significance in the assessment of the severity of the disease and prognosis.