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本文报告一种完全合成的低分子量肽无载体口蹄疫病毒(FMDV)疫苗.该疫苗由合成的B细胞和巨噬细胞活化剂构成,其与两性分子α螺旋状T细胞抗原决定簇共价联接.3.4千道尔顿(KDa)低分子量FMDV疫苗是由相应于FMDV蛋白序列的合成的VP1(135～154)和三棕榈酰-S-甘油基-半胱氨酰丝氨酰丝氨酸(P_3CSS)佐剂构成.P_3CSS是合成的革兰阴性菌脂蛋白氨基末端部分的类似物.抗原决定簇VP1(135～154)通过圆二色性证明是一种α螺旋.这种新型的
This article reports a fully synthetic low molecular weight peptide carrier-free foot-and-mouth disease virus (FMDV) vaccine consisting of synthetic B-cell and macrophage activators covalently linked to amphipathic alpha helical T-cell epitopes. 3.4 The KDa Low Molecular Weight FMDV Vaccine is a combination of the synthetic VP1 (135-154) and tripalmitoyl-S-glycero-cystosylserine serine (P_3CSS) corresponding to the FMDV protein sequence P3.CSS is an analogue of the amino terminal portion of a synthetic gram-negative bacterial lipoprotein.The antigenic determinant VP1 (135-154) proved to be an alpha helix by circular dichroism. This novel