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噻唑烷二酮(TZD)类药物通过提高脂肪和肌肉等外周组织对胰岛素的敏感性,使内源性和外源性胰岛素的作用增强,从而改善血糖控制,并延缓β细胞功能减退。马来酸罗格列酮片(商品名文迪雅)是一种疗效最强的TZD,其传统适应症为治疗2型糖尿病,单用并辅以饮食控制和运动,可控制2型糖尿病的血糖;对于血糖控制不佳者,可与二甲双胍或磺酰脲类药物联用。2003年2月27日,美国FDA批准了文迪雅的一项新适应症,即文迪雅与胰岛素联用治疗2型糖尿病。文迪雅与胰岛素联用为2型糖尿病的治疗开辟了一条崭新的途径。
Thiazolidinediones (TZDs) improve glycemic control and retard β-cell dysfunction by increasing the insulin sensitivity of peripheral tissues such as fat and muscle to enhance the effects of endogenous and exogenous insulin. The rosiglitazone maleate tablet (Avandia) is the most potent TZD whose traditional indications are for type 2 diabetes, alone and supplemented with dietary control and exercise to control type 2 diabetes Blood glucose; poor blood sugar control, with metformin or sulfonylurea combination. February 27, 2003, the United States FDA approved a new indication of Avandia, Avandia and insulin in the treatment of type 2 diabetes. Avandia and insulin for the treatment of type 2 diabetes has opened up a new way.