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目的:探讨β-HCG、妊娠相关蛋白A(PAPP-A)在妊娠滋养细胞疾病诊断和治疗中的应用。方法:选择2006年6月～2009年10月河南省直人民医院妊娠滋养细胞疾病患者51例,选择2009年8～11月该院正常孕妇14例作为对照组,应用ELISA法检测患者及正常孕妇的血清PAPP-A、β-HCG的含量。结果:良性葡萄胎组和侵蚀性葡萄胎组β-HCG水平明显高于对照组(P<0.05),良性葡萄胎组PAPP-A水平明显高于对照组及侵蚀性葡萄胎组(P<0.05),而侵蚀性葡萄胎组PAPP-A水平明显低于良性葡萄胎组及对照组(P<0.05),葡萄胎恶变组清宫术前β-HCG水平明显高于良性转归组(P<0.05),而PAPP-A明显低于良性转归组(P<0.05)。侵蚀性葡萄胎组治疗前PAPP-A水平与临床分期呈负相关。结论:β-HCG、PAPP-A在妊娠滋养细胞疾病的诊断、鉴别诊断、转归、预后及临床分期中均具有重要意义。
Objective: To investigate the application of β-HCG and pregnancy-associated protein A (PAPP-A) in the diagnosis and treatment of gestational trophoblastic diseases. Methods: From June 2006 to October 2009, 51 patients with gestational trophoblastic disease in People’s Hospital of Henan Province were selected. 14 normal pregnant women in this hospital from January to August in 2009 were selected as the control group. ELISA and ELISA were used to detect patients and normal pregnant women Of serum PAPP-A, β-HCG content. Results: The level of β-HCG in benign hydatidiform mole and invasive hydatidiform mole group was significantly higher than that in control group (P <0.05). The PAPP-A level in benign hydatidiform mole group was significantly higher than that in control group and invasive hydatidiform mole group (P <0.05) ), While the level of PAPP-A in invasive hydatidiform mole group was significantly lower than that in benign hydatidiform mole group and control group (P <0.05). The level of β-HCG in malignant hydatidiform mole group was significantly higher than that in benign outcome group ), While PAPP-A was significantly lower than the benign outcome group (P <0.05). The level of PAPP-A in invasive hydatidiform mole group was negatively correlated with clinical stage. Conclusion: β-HCG and PAPP-A are of great importance in the diagnosis, differential diagnosis, prognosis, prognosis and clinical stage of gestational trophoblastic diseases.