论文部分内容阅读
以近期发表的文献为依据,从分析苯妥英的体内代谢过程和基因诊断的基本理论,以及介绍成功应用基因诊断于苯妥英临床合理应用的实例入手,对利用基因诊断提高苯妥英合理应用水平的理论依据、临床意义、具体方法及适用范围等进行全面的阐述.基因多态是影响苯妥英药效学、药动学和药物不良反应的重要因素.基因诊断可成为提高苯妥英合理应用的有效方法,在苯妥英钠治疗癫痫病中应得到广泛的应用.“,”To analyze in vivo the metabolic process of phenytoin and the basic theories of gene diagnosis, and introduce the examples of successful application of gene diagnosis in clinical phenytoin usage, and thoroughly expound the theoretical basis, clinical relevance, specific methods, and fields of application of using gene diagnosis to improve the usage of phenytoin, using recently published literature as a basis. The genetic polymorphism is an important factor that affects the pharmacodynamics, pharmacokinetics, and drug adverse reaction of phenytoin. Gene diagnosis may become an effective way of improving usage of phenytoin and should be used widely in treating epilepsy with phenytoin.