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2例男性膀胱癌术后患者于膀胱灌注表柔比星或吡柔比星后出现过敏反应。例1为60岁男性患者,接受表柔比星50mg加入0.9%氯化钠注射液50ml膀胱灌注。灌注约10min后,患者出现手足发痒,面部及四肢发红,心率100次/min;20min后,症状加重,患者无法忍受,遂排空化疗药物。排空后症状缓解并逐渐消失。随后再行第2次表柔比星膀胱灌注,出现上述表现,并伴有恶心、呕吐,经排空药物,全身症状消失。例2为54岁男性患者,接受吡柔比星40mg加入5%葡萄糖注射液50ml膀胱灌注化疗。灌注30min时,患者出现视力模糊,全身发痒,伴风团。立即排空膀胱,并给予苯海拉明及地塞米松肌内注射。30min后症状减轻,1h后消失。
Two cases of postoperative bladder cancer patients showed allergic reactions after intravesical instillation of epirubicin or pirarubicin. Example 1 A 60-year-old male patient received 50 ml of epirubicin plus 0.9% sodium chloride injection in a bladder infuse. After about 10 minutes of perfusion, the patients presented itchy hand, redness of the face and limbs, and the heart rate was 100 beats / min. After 20 minutes, the symptoms were aggravated and the patients could not tolerate the chemotherapy drugs. After emptying symptoms ease and gradually disappear. Followed by the second epirubicin intravesical instillation, the above performance, accompanied by nausea, vomiting, after emptying the drug, systemic symptoms disappear. Example 2 A 54-year-old male patient received pirarubicin 40mg plus 5% glucose injections in a 50ml bladder infusion chemotherapy. 30min perfusion, patients with blurred vision, systemic itching, accompanied by wind group. Immediately empty the bladder and give diphenhydramine and dexamethasone intramuscularly. Symptoms were relieved after 30 minutes and disappeared after 1 hour.