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手性是自然界的本质属性之一,作为生命活动重要物质基础的生物大分子和许多作用于受体的活性物质均具有手性特征,因此分子的不对称性在生命过程中起着重要作用.近年来,随着不对称合成和手性开关技术的迅速发展,单一对映体的工业化生产成为可能.L-苯丙氨酸是人和动物必需的氨基酸,不能在体内合成,必须从外界摄取,近年来由于它在医药制剂和高甜度天冬甜精等方面的需求量剧增,对其研究和开发日益增多.酶膜反应萃取器集固定化酶膜反应与液液萃取于一体,能大大提高反应和分离效率,Matson、Scheper、Ha、Chang等利用酶膜反应萃取和乳化液膜酶反应过程,已成功地实现了一些消旋物的拆分.本文选择苯丙氨酸的拆分为研究对象,利用酶膜反应萃取过程进行L-苯丙氨酸的合成,探讨过程的可行性和影响因素.
Chirality is one of the essential properties in nature. As biological macromolecules, which are the important material of life activity, and many active substances acting on the receptors, they have chiral characteristics. Therefore, the asymmetry of molecules plays an important role in the life process. In recent years, with the rapid development of asymmetric synthesis and chiral switching technology, the industrial production of a single enantiomer is possible.L-phenylalanine is an essential amino acid for human and animal and can not be synthesized in the body and must be taken from outside In recent years, due to its dramatic increase in the demand for pharmaceutical preparations and high-sweetness aspartame, it has been increasingly researched and developed.Enzyme Membrane Reactor combines immobilized enzyme membrane reaction and liquid-liquid extraction in one, Can greatly improve the reaction and separation efficiency, Matson, Scheper, Ha, Chang, etc. using enzymatic membrane reaction and emulsion liquid membrane enzyme reaction process, has successfully achieved some resolution of racemate.In this paper, the choice of phenylalanine demolition Divided into the research object, the use of enzyme membrane reaction extraction process of L-phenylalanine synthesis, to explore the feasibility of the process and influencing factors.