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目的了解谷胱甘肽（GSH）对感染后组织器官损伤的保护作用。方法将家兔分为实验组和对照组。实验组预先肌肉注射GSH保护；对照组分为对照1组，未做手术正常对照；对照2组为手术感染组；对照3组为假手术组。实验组和感染对照组在腹腔通过手术造成感染。分别测定各组家兔的肝肾功能，心肝肾各组织中GSH含量和红细胞膜流基含量及Na+－K+－ATP酶活性。结果用外源性GSH保护组与感染组对照比较，肝肾功能损害较轻；红细胞膜巯基含量和钠钾ATP酶活性增加。结论外源性GSH对感染引起的器官损伤有保护作用。
Objective To understand the protective effect of glutathione (GSH) on tissue and organ injury after infection. Methods Rabbits were divided into experimental group and control group. The experimental group was pre-injected intramuscularly with GSH protection. The control group consisted of control group 1 and no normal control group. The control group 2 was infected by surgery group and the control group 3 was sham-operated group. The experimental group and infection control group caused infection in abdominal cavity through surgery. The liver and kidney function, the content of GSH, the content of erythrocyte membrane-based and the activity of Na + -K + -ATPase in each group were determined. Results Compared with the control group, the exogenous GSH protective group showed less damage to liver and kidney, and the content of sulfhydryl group and the activity of Na +, K + -ATPase increased. Conclusion Exogenous GSH has a protective effect on organ injury caused by infection.