某些药物可引起眼部毒性。1993年德国报告了两例静脉注射奥美拉唑引起失明,并提出了可能的发生机制及怀疑与曾经报道口服奥美拉唑与视力损害关系相似。通过联合国临床医师研究资料库,作者对口服抗溃疡药与眼严重炎症及血管病变的关系进行了回顾性的调查。 研究对象年龄在20～74岁。从1990年1月至1993年11月,他们均接受至少一张处方的西米替丁、法莫替丁、尼扎替丁、奥美拉唑或雷尼替丁的治疗。这些研究对象的既往史中已排除选择性眼疾、脑血管病、癌症、多发性硬化、脑病、高血压及糖尿病。人 Some drugs can cause eye toxicity. In 1993, Germany reported two cases of intravenous injection of omeprazole cause blindness, and put forward the possible mechanism and suspicion of oral omeprazole has been reported and the relationship between visual impairment and similar. Through the UN Clinician Research Database, the authors conducted a retrospective review of the relationship between oral antiulcer drugs and severe eye inflammation and vascular disease. The subjects were 20 to 74 years old. From January 1990 to November 1993, they all received treatment with cimetidine, famotidine, nizatidine, omeprazole, or ranitidine in at least one prescription. Selective eye diseases, cerebrovascular disease, cancer, multiple sclerosis, encephalopathy, hypertension and diabetes have been excluded from the past history of these subjects. people