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目的：探讨用蛋白芯片法检测CA199和CA242在胰腺癌诊断中应用价值。方法用蛋白芯片法测定测定血清CA199和CA242水平。分别测定胰腺癌的患者(病例组60例)、胰腺良性疾病患者(对照组60例)的CA199和CA242水平。结果胰腺癌患者血清中肿瘤标志物CA199和CA242的水平明显高于对照组，组间比较，差异有统计学意义(<0.05)，病例组CA199和CA242的敏感性和特异性高于对照组，差异有统计学意义(<0.05)，玉期和Ⅱ期患者胰腺癌血清肿瘤标志物水平显著低于芋期，差异有统计学意义(<0.05)。结论检测CA199和CA242有利于胰腺癌临床诊断，可作为诊断胰腺癌的一项筛选指标。“,”Objective To investigate the value of detection of CA199 and CA242 by application of protein chip in diagnosis of pancreatic carcinoma.Methods CA199 and CA242 were determined and analyzed in 60 patients with pancreatic carcinoma,60 patients with non-pancreatic tumors.Results The serum levels of CA199 and CA242in patients with pancreatic cancer were significantly higher than those in the patients with pancreatic benign lesion ( <0.05).The sensitivity and specificity of CA199 and CA242 in case group was higher than control group,the dif erence has statistical significance ( <0.05).Phase I and I tumor marker for pancreatic carcinoma was lower than Phase I I,the dif erence was significant ( <0.05).Conclusion The detection of CA199 and CA242 is helpful for clinical diagnosis of pancreatic cancer,and can be used as a screening index for the diagnosis of pancreatic carcinoma.