嗜银细胞主要见于胃、肠、阑尾和支气管等处。由嗜银细胞发生的肿瘤有类癌、不典型类癌和小细胞癌等,临床病理诊断时常需要和腺癌、硬癌及未分化癌等进行鉴别。嗜银染色对嗜银细胞瘤的确诊是一个稳定、可靠的好方法,但操作步骤多、所需时间长,常延误诊治时间,尤其是来源于后肠的嗜银细胞瘤,银反应常为阴性。我们应用甲醛诱发荧光技术,观察了来源于不同部位的嗜银细胞瘤和胃腺癌、硬癌、肺未分化癌等几种容易与嗜银细胞瘤相混淆的肿瘤,结果在荧光显微镜下发现,嗜银细胞瘤的胞浆中有不同强度的金黄色荧光,而与它容易混淆的几种肿瘤则无这种荧光。因此我们认为,嗜银细胞瘤经甲醛处理后产生金黄色荧光这一特征,可作为一种鉴别嗜银细胞瘤的实用方法,用于日常病理诊断工作中。此方法识别嗜银细胞具有敏感性高、特异性强、操作简单、快速和经济实用等优点,便于在具有荧光显微镜的单位应用和推广。 Argyrophil cells are mainly found in the stomach, intestine, appendix and bronchi. The tumors that arise from argent cells include carcinoids, atypical carcinoids, and small cell cancers. Clinicopathologic diagnosis often requires the identification of adenocarcinoma, hard cancer, and undifferentiated cancer. Silver staining is a stable and reliable method for definitive diagnosis of arachophilic sarcoma, but it requires many steps and takes a long time. It often delays diagnosis and treatment, especially from the ileus of the back ileon. The silver reaction is often negative. Using formaldehyde-induced fluorescence technology, we observed erythrocyte tumors from different sites, and gastric cancers, hard cancers, and lung undifferentiated cancers. These tumors were easily confused with argyrophil tumors and were found under a fluorescence microscope. The cytoplasm of argyrinocytoma has golden fluorescence with different intensities, and several tumors that are easily confused with it do not have such fluorescence. Therefore, we believe that the argythropoietin treatment of formaldehyde produces golden fluorescence, which can be used as a practical method for the identification of argyrophil tumors and used in routine pathological diagnosis. This method recognizes that argyrophil cells have the advantages of high sensitivity, strong specificity, simple operation, rapidness, economy, and practicality, and are convenient for application and promotion in units with fluorescent microscopes.