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目的探讨降钙素原水平改变在急性胰腺炎并发感染中的临床意义。方法 35例急性胰腺炎患者,根据是否合并有感染分为并发感染组(20例)和非并发感染组(15例)。测定两组患者的体温、白细胞计数、降钙素原及C反应蛋白水平,对患者进行急性生理及慢性健康标准(APACHE-Ⅱ)评分。结果两组患者体温、C反应蛋白水平、白细胞计数、APACHE-Ⅱ评分比较,差异无统计学意义(P>0.05);并发感染组降钙素原水平高于非并发感染组,差异有统计学意义(P<0.05)。结论降钙素原水平在急性胰腺炎并发感染患者中水平升高,且高于急性胰腺炎无并发感染患者,观察降钙素原水平改变有助于急性胰腺炎并发感染诊断,利于预测此类患者预后。
Objective To investigate the clinical significance of the alteration of procalcitonin in the complication of acute pancreatitis. Methods Thirty-five patients with acute pancreatitis were divided into concurrent infection group (n = 20) and non-concurrent infection group (n = 15) according to whether the infection was complicated or not. The body temperature, white blood cell count, procalcitonin and C-reactive protein levels were measured in both groups, and the APACHE-Ⅱ scores were evaluated. Results There was no significant difference in body temperature, C-reactive protein level, leukocyte count and APACHE-Ⅱ score between the two groups (P> 0.05). The level of procalcitonin in the concurrent infection group was higher than that in the non-concurrent infection group Significance (P <0.05). CONCLUSIONS: The level of procalcitonin is elevated in patients with acute pancreatitis complicated with infection and higher than that in patients with acute pancreatitis without concomitant infection. The observation that changes in procalcitonin level may contribute to the diagnosis of acute pancreatitis complicated with infection may be helpful for predicting this type of infection Patient’s prognosis.