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目的了解宜宾地区2011年-2014年间肺炎克雷伯菌的临床分布特点及耐药情况,为临床合理选用抗菌药物提供依据。方法收集宜宾市第一人民医院和宜宾市第二人民医院2011年-2014年从各类临床标本中分离出的肺炎克雷伯菌,用VITEK2 Compact及配套的鉴定卡GP与药物敏感性测试卡AST-GP67进行检测,并对结果进行分析总结。结果呼吸内科为检出肺炎克雷伯菌的主要科室,2011年-2014年各年构成比依次为48.15%、46.24%、45.44%、44.97%;肺炎克雷伯菌主要从痰标本中分离出,2011年-2014年各年构成比依次为81.01%、89.18%、87.80%、83.52%。亚胺培南、哌拉西林/他唑巴坦耐药率较低,但总体呈上升趋势;氨苄西林/舒巴坦、磺胺甲噁唑耐药率较高;左氧氟沙星、环丙沙星耐药率呈上升趋势;氨曲南、头孢比肟、阿米卡星耐药率呈下降趋势。结论肺炎克雷伯菌为呼吸科主要的感染病原学之一,其耐药率高,对加酶抑制剂β-内酰胺类抗菌药物或碳青霉烯类抗菌药物敏感。
Objective To understand the clinical distribution and drug resistance of Klebsiella pneumonia in Yibin from 2011 to 2014, and provide basis for the rational use of antibacterials in clinic. Methods The First People’s Hospital of Yibin City and the Second People’s Hospital of Yibin City from 2011 to 2014 were isolated from various clinical specimens of Klebsiella pneumoniae, with VITEK2 Compact and matching identification card GP and drug sensitivity test card AST-GP67 for testing, and analysis of the results summary. Results Respiratory medicine was the main department of detection of Klebsiella pneumoniae. The constituent ratios of each year from 2011 to 2014 were 48.15%, 46.24%, 45.44% and 44.97%, respectively. Klebsiella pneumoniae was mainly isolated from sputum The composition ratios of each year from 2011 to 2014 are 81.01%, 89.18%, 87.80% and 83.52% respectively. Imipenem and piperacillin / tazobactam rates were lower, but the overall trend was upward. Ampicillin / sulbactam and sulfamethoxazole were more resistant rates; levofloxacin and ciprofloxacin resistance The rates of aztreonam, ceftibioxime and amikacin showed a decreasing trend. Conclusions Klebsiella pneumoniae is one of the major infectious etiologies in respiratory department. It has high resistance rate and is sensitive to β-lactam antibiotics or carbapenem antibiotics.