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目的 探讨非小细胞肺癌的影像学表现与其癌细胞rasp2 1表达的关系。资料与方法 利用免疫组化LSAB法测定经手术及病理证实的 46例外围型非小细胞肺癌组织中rasp2 1的表达强度 ,分析其表达特点与影像学征象的相关关系。结果 外围型非小细胞肺癌的临床分期与癌细胞rasp2 1表达强度密切相关 (P <0 .0 1 ) ;肿块大小在rasp2 1表达阳性组和阴性组的出现率具有显著性差异 (P <0 .0 1 ) ,肿块毛刺征、三级支气管受累在rasp2 1表达阳性组的出现率明显高于阴性组 (P <0 .0 1 )。但分叶征、胸膜凹陷征及肺门纵隔淋巴结肿大在rasp2 1表达阳性组、阴性组的出现率无显著性差异 (P >0 .0 5)。结论 外围型非小细胞肺癌的某些影像学表现如肿块毛刺征、三级支气管受累及肿块大小等与其癌细胞rasp2 1的表达具有密切的关系
Objective To investigate the relationship between the radiological manifestations of non-small cell lung cancer and the expression of rasp21 in cancer cells. Materials and Methods The expression of rasp21 in 46 cases of peripheral non-small cell lung cancer confirmed by surgery and pathology was determined by immunohistochemical LSAB method. The correlation between the expression characteristics and radiological signs was analyzed. Results The clinical staging of peripheral non-small cell lung cancer was closely related to the intensity of rasp21 expression in cancer cells (P < 0.01). The incidence of tumor size in the positive and negative groups of rasp21 expression was significantly different (P <0 .0 1) The incidence of tumor burr and grade 3 bronchial involvement in the rasp2 1 positive group was significantly higher than that in the negative group (P < 0.01). However, there was no significant difference in the frequency of lobectomy sign, pleural recession, and mediastinal lymph node enlargement between rasp1 1 positive and negative groups (P > 0.05). Conclusion Some imaging features of peripheral non-small cell lung cancer, such as tumor burr, grade 3 bronchial involvement and tumor size, have close relationship with the expression of rasp2 1 in cancer cells.