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目的分析手术治疗前后胃癌患者血清血管内皮生长因子(VEGF)、基质金属蛋白酶-3(MMP-3)的变化。方法 50例胃癌患者,随机分为腔镜组和开腹组,每组25例,另选取同期进行体检的25例健康人员作为对照组。对比三组受试者术前、术后1周、1、6个月血清VEGF、MMP-3的变化。结果术前腔镜组和开腹组患者的血清VEGF、MMP-3水平差异无统计学意义(P>0.05),但均明显比对照组高,差异具有统计学意义(P<0.05);术后1周、术后1个月腔镜组患者的血清VEGF、MMP-3均明显比开腹组低,但明显比对照组高,差异具有统计学意义(P<0.05);术后6个月腔镜组和开腹组患者的血清VEGF、MMP-3水平比较差异无统计学意义(P>0.05),血清MMP-3水平与对照组比较,差异无统计学意义(P>0.05),但血清VEGF水平仍均明显比对照组高,差异具有统计学意义(P<0.05)。结论胃癌患者血清VEGF、MMP-3水平在手术治疗后较治疗前明显下降,腹腔镜胃癌根治术较开腹手术对患者的机体功能具有较小的影响,安全可行。
Objective To analyze the changes of serum vascular endothelial growth factor (VEGF) and matrix metalloproteinase-3 (MMP-3) in patients with gastric cancer before and after operation. Methods Fifty patients with gastric cancer were randomly divided into laparoscopic group and laparotomy group, with 25 cases in each group. 25 healthy people who took physical examination in the same period were selected as the control group. The changes of serum VEGF and MMP-3 in three groups were compared before and after 1 week and 1 and 6 months after operation. Results There was no significant difference in serum VEGF and MMP-3 levels between preoperative group and open group (P> 0.05), but both were significantly higher than those in control group (P <0.05) After one week and one month after operation, the serum levels of VEGF and MMP-3 in the endoscopic group were significantly lower than those in the open group, but significantly higher than those in the control group (P <0.05); after 6 There was no significant difference in serum VEGF, MMP-3 levels between the patients with laparoscopic and open laparoscopic groups (P> 0.05). There was no significant difference in serum MMP-3 levels between the two groups (P> 0.05) However, serum VEGF levels were still significantly higher than the control group, the difference was statistically significant (P <0.05). Conclusions Serum levels of VEGF and MMP-3 in patients with gastric cancer are significantly lower than those before treatment after laparoscopic surgery. Laparoscopic radical gastrectomy has less effect on the patient’s body function than laparotomy, which is safe and feasible.