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目的分析血清抗苗勒管激素对体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法随机选取185例进行IVF-ET治疗的患者,于月经第2~4天测定血清促卵泡刺激素(FSH)、血清促黄体生成素(LH)和血清雌二醇(E_2)水平,同时用超声行卵巢窦卵泡计数(AFC);在超促排卵治疗前测定血清抗苗勒管激素(AMH)水平;根据新鲜周期和冷冻胚胎复苏周期移植妊娠结局分组比较各观察指标。结果 1血清AMH与获卵数、成熟卵数、受精卵数、可移植胚胎数和优质胚胎数均有显著相关性(P<0.001)。2血清AMH与临床妊娠率无统计学差异(P>0.05),但在新鲜周期移植中,血清AMH与临床妊娠率呈正相关(P<0.05),有统计学意义。3血清AMH不能预测IVF-ET的妊娠结局(ROC-AUC=0.483)。结论 1血清AMH与获卵数、成熟卵数、受精卵数、可移植胚胎数和优质胚胎数有显著相关性。2血清AMH不能预测IVF-ET的妊娠结局,在新鲜周期移植中,血清AMH与年龄较小患者的临床妊娠率有相关性。
Objective To analyze the effect of serum anti-Mullerian hormone on pregnancy outcome of IVF-ET. Methods A total of 185 patients undergoing IVF-ET were randomly selected. Serum follicle stimulating hormone (FSH), serum luteinizing hormone (LH) and serum estradiol (E2) levels were measured at 2 to 4 days after menstruation. Ultrasound was used to measure the ovarian antral follicle count (AFC). Serum anti-Mullerian hormone (AMH) levels were measured before superovulation treatment. Pregnancy outcomes were compared according to the fresh cycle and frozen embryo resuscitation cycle. Results 1 Serum AMH was significantly correlated with the number of oocytes retrieved, number of mature eggs, number of fertilized eggs, number of transferable embryos and number of high quality embryos (P <0.001). Serum AMH had no significant difference with clinical pregnancy rate (P> 0.05). However, there was a positive correlation between serum AMH and clinical pregnancy rate (P <0.05) in fresh cycle transplantation. 3 Serum AMH failed to predict the pregnancy outcome of IVF-ET (ROC-AUC = 0.483). Conclusions1 Serum AMH has a significant correlation with the number of oocytes retrieved, the number of mature eggs, the number of fertilized eggs, the number of transplanted embryos and the number of high quality embryos. 2 serum AMH can not predict the pregnancy outcome of IVF-ET. Serum AMH is associated with the clinical pregnancy rate of younger patients in fresh-cycle transplantation.