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为了探讨联合应用乙型肝炎免疫球旦白(HBIG)和乙型肝炎(HB)疫苗预防HBV围产期传播的效果,作者筛选了18,842名孕妇,并选择HBsAg和HBeAg阳性孕妇分娩的113名健康婴儿做为研究对象.婴儿于出生后24小时内肌肉注射HBIG0.5ml,接种3剂HB疫苗,每剂20μg.A组于注射HBIG的同时开始接种疫苗,B组在出生后1个月开始接种疫苗,以后间隔1个月和6个月接种第2剂和第3剂疫苗.婴儿出生时收集脐血,接种前收集静脉血.随访9～18个月,分别收集血标本(A组:1、3、6、9、12和18个月;B组:1、2、6、9、12、18个月).在婴儿出生时或出生后收集母血进一步检测HBsAg和
To explore the effect of combined use of hepatitis B immunoglobulin (HBIG) and hepatitis B (HB) vaccines in the prevention of HBV perinatal transmission, the authors screened 18,842 pregnant women and selected 113 healthy children of HBsAg and HBeAg-positive mothers The infants were intramuscularly injected with 0.5 ml of HBIG intramuscularly within 3 hours after birth, and 3 doses of HB vaccine were given at a dose of 20 μg per dose.A group was vaccinated at the same time of HBIG injection and group B was inoculated one month after birth Vaccines were administered at doses of one and six months later with doses of 2 and 3. The cord blood was collected at birth and venous blood was collected prior to vaccination.The blood samples were collected from 9 to 18 months of follow-up (group A: , 3, 6, 9, 12 and 18 months; Group B: 1, 2, 6, 9, 12 and 18 months). Maternal blood was collected at or after birth to further detect HBsAg and