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上海第一医学院华山医院于1963年在动物实验基础上采用肿瘤自体疫苗治疗21例恶性脑瘤,经过一年左右的随访,发现该疗法虽可使部分病例的体重增加,食欲,精神、及一般情况好转,但总的生存时间未见延长,未能改善恶性脑瘤的不良预后。作者认为,疗效不佳的主要原因之一是患肿瘤的机体不一定都能识别其体内的肿瘤抗元,因此亦不能产生相应的免疫(排异)反应;为了提高肿瘤疫苗的疗效,必须改变其抗元
Huashan Hospital of Shanghai First Medical College used tumor autologous vaccine to treat 21 cases of malignant brain tumor on the basis of animal experiments in 1963. After a year or so of follow-up, it was found that this therapy can increase body weight, appetite, spirit and The general situation improved, but the total survival time was not extended and failed to improve the poor prognosis of malignant brain tumors. The author believes that one of the main reasons for poor efficacy is that the body with the tumor may not always be able to identify the body’s tumor resistance, and therefore it cannot produce a corresponding immune (rejection) response; in order to improve the efficacy of the tumor vaccine, must be changed Anti-elements