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目的 对早年从事放射工作的人员进行剂量重建。方法 用 1#、4 #全染色体探针进行荧光原位杂交 (FISH)分析了 2 2名探伤人员及 10名对照者的染色体畸变。结果 探伤人员染色体易位率、总畸变率显著高于对照组 ,二者差异有统计学意义 ;染色体易位率随探伤工龄增加而增加 ;探伤人员生物剂量与物理剂量比较基本一致。结论 用FISH方法检测染色体畸变对早期受照射人员进行剂量重建是可行的。
Objective To reconstruct the dose of radiation used in early years. Methods The chromosomal aberrations of 22 testing workers and 10 controls were analyzed by fluorescence in situ hybridization (FISH) with 1 # and 4 # full chromosome probes. Results The chromosomal translocation rate and total aberration rate of testing staff were significantly higher than those of the control group. The difference was statistically significant. The rate of chromosomal translocation increased with the increase of testing age. The biological dosage of testing staff was basically the same as that of physical dosage. Conclusion FISH detection of chromosomal aberrations is feasible for early radiation dose reconstruction.