应用左旋多巴治疗震颤麻痹综合症(帕金森氏综合症)系根据“纹状体多巴胺缺乏”的神经介质概念而来。左旋多巴透过血脑屏障后,通过大脑的芳香 L-氨基酸脱羧酶的作用变成多巴胺,从而补充了多巴胺的消耗。对于许多震颤麻痹症患者,单用左旋多巴治疗常常是不够的。因此,在临床实践中,它常与其它强力药物联合应用。本文介绍可能影响震颤麻痹症处理的一些相互作用的因素。 Treatment of Parkinsonism syndrome (Parkinson’s disease) with levodopa is based on the neurotransmitter concept of “striatal dopamine deficiency.” Levodopa, after passing through the blood-brain barrier, becomes dopamine through the action of the aromatic L-amino acid decarboxylase in the brain, thereby replenishing dopamine. For many paralysis patients, treatment with levodopa alone is often not enough. Therefore, in clinical practice, it is often used in combination with other powerful drugs. This article describes some of the factors that may affect the treatment of Parkinsonism.