目的:研究电刺激大鼠伏隔核(nucleus accumbens,NAC)对腹侧苍白球(ventral pallidum,VP)神经元放电的影响,探索电刺激NAC治疗药物成瘾的机制。方法:本实验应用细胞外记录方法观察不同频率电刺激(强度0.4mA,波宽0.06ms,时程5s,频率5,10,20,50,80,100,130,150和200Hz)大鼠NAC对VP神经元放电的影响。结果:刺激频率低于20Hz时,大多数VP神经元的放电频率无变化,电刺激频率大于20Hz可使大多数VP神经元的放电频率降低。结论:本研究提示高频刺激NAC对药物依赖可能有治疗作用。 Objective: To investigate the effect of electrical stimulation of nucleus accumbens (NAC) on the discharge of ventral pallidum (VP) neurons in rats and explore the mechanism of electrical stimulation of NAC in drug addiction. Methods: The extracellular recording method was used to observe the discharge of VP neurons by NAC in different frequency electrical stimulation (intensity 0.4mA, wave width 0.06ms, duration 5s, frequency 5, 10,20,50,80,100,130,150 and 200Hz) influences. Results: When the stimulation frequency was lower than 20Hz, the discharge frequency of most VP neurons did not change. When the stimulation frequency was greater than 20Hz, the discharge frequency of most VP neurons decreased. Conclusion: This study suggests that high-frequency stimulation of NAC may have a therapeutic effect on drug dependence.