论文部分内容阅读
B7-CD28家族共刺激信号分子在T淋巴细胞激活、抑制机体耐受及产生理想的T细胞免疫应答等方面起着关键作用。B7-CD28家族共信号分子已经被集中的研究,并且引起免疫调控领域充分的重视。CD80/CD86/CD28/CTLA-4经典途径的新功能的发现以及这一家族包括B7-H1/B7-DC/PD-1,B7-H2/ICOS,B7-H4和BTLA的新途径的确定,都拓宽了我们对T细胞介导的免疫应答和免疫耐受调控的理解。本文就CTLA-4、PD-1和BTLA对T细胞应答的负性调节以及在维持外周耐受中起作用的研究进展作一综述。
B7-CD28 family of costimulatory molecules plays a key role in the activation of T lymphocytes, the inhibition of the tolerance of the body and the generation of an ideal T-cell immune response. The B7-CD28 family of signaling molecules has been studied intensively and has given full prominence to the field of immunological regulation. The discovery of new functions of the CD80 / CD86 / CD28 / CTLA-4 classical pathway as well as the identification of new pathways for this family including B7-H1 / B7-DC / PD-1, B7-H2 / ICOS, B7-H4 and BTLA, Have broadened our understanding of T cell-mediated immune response and immune tolerance regulation. This review summarizes the negative regulatory effects of CTLA-4, PD-1 and BTLA on T cell responses and their roles in maintaining peripheral tolerance.