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目的探讨阿托伐他汀与瑞舒伐他汀对冠状动脉内支架植入(PCI)术后血清单核细胞趋化因子-1(MCP-1)、白细胞介素-10(IL-10)及其比值的影响,以期为他汀类药物抗炎机制的研究提供参考,为PCI术后阿托伐他汀与瑞舒伐他汀药物的选择提供一定的理论依据。方法选择接受支架植入的冠心病患者200例,随机分为两组,每组100例,两组分别于术后给予阿托伐他汀20mg和瑞舒伐他汀20mg口服,持续服药2周以上,于术前、术后24h和术后2周分别采集患者静脉血,用酶联免疫吸附法(ELISA)测定MCP-1和IL-10水平,比较两组间的差异。结果 PCI术后24h患者MCP-1和IL-10水平均高于术前(P<0.05),术后2周给予两种药物的患者静脉血中IL-10和MCP-1水平与术后24h比较均降低,后者差异有统计学意义(P<0.05)。术后2周服用瑞舒伐他汀的患者MCP-1水平降低值和MCP-1/IL-10比值下降值均较服用阿托伐他汀的差异有统计学意义(P<0.05),但两种药物对IL-10水平的影响无统计学意义。结论 PCI术可显著增加术后患者血中IL-10和MCP-1水平,瑞舒伐他汀和阿托伐他汀均能显著降低术后血中MCP-1水平,且瑞舒伐他汀的降MCP-1效果比阿托伐他汀更优,对IL-10水平的影响两者差异无统计学意义。
Objective To investigate the effects of atorvastatin and rosuvastatin on serum levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-10 (IL-10) and their receptors in patients undergoing coronary stent implantation Ratio, to provide a reference for the study of anti-inflammatory mechanism of statins and provide some theoretical basis for the choice of atorvastatin and rosuvastatin drugs after PCI. Methods 200 patients with coronary artery disease undergoing stent implantation were randomly divided into two groups of 100 patients. The two groups were given oral atorvastatin 20mg and rosuvastatin 20mg orally respectively for more than two weeks, Venous blood samples were collected before operation, 24h after operation and two weeks after operation. The levels of MCP-1 and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA), and the differences between the two groups were compared. Results The levels of MCP-1 and IL-10 in 24h patients after PCI were significantly higher than those before operation (P <0.05). The levels of IL-10 and MCP-1 in venous blood of two patients given two drugs two weeks after operation were significantly lower than those before operation The difference was statistically significant (P <0.05). MCP-1 levels and MCP-1 / IL-10 ratio decreased significantly in patients taking rosuvastatin 2 weeks after surgery compared with taking atorvastatin (P <0.05), but both The effects of drugs on IL-10 levels were not statistically significant. Conclusions PCI can significantly increase the levels of IL-10 and MCP-1 in postoperative patients. Both rosuvastatin and atorvastatin can significantly reduce the level of MCP-1 in postoperative blood, and rosuvastatin reduces MCP -1 is better than atorvastatin, and there is no significant difference between them on the level of IL-10.