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目的:比较国产缬沙坦和进口缬沙坦治疗轻、中度高血压的疗效及安全性。方法:156例轻、中度高血压患者随机分为两组,试验组(n=84)口服国产缬沙坦,对照组(n=72)服用进口缬沙坦,用法均为80 mg,qd。血压下降未达到有效标准时,药物剂量增加1倍。治疗时间均为8周。结果:8周后试验组血压由(148.8±6.2)/(98.6±2.2)mmHg分别降至(126.5±3.8)/(81.7±2.2)mmHg;对照组由(147.5±2.9)/(99.2±2.6)mmHg分别降至(125.7±4.9)/(80.9±2.0)mmHg,两组较服药前均有显著降低(P<0.01),试验组与对照组总有效率分别为86.9%和88.8%(P>0.05)。两组心率无明显变化,治疗期间均未见明显不良反应。结论:国产缬沙坦与进口缬沙坦对轻中度原发性高血压具有相似的降压效果,且不影响心率,不良反应少。
Objective: To compare the efficacy and safety of domestic valsartan and valsartan in the treatment of mild and moderate hypertension. Methods: A total of 156 mild and moderate hypertensive patients were randomly divided into two groups: the control group (n = 84) and the control group (n = 84) received valsartan orally. All the patients were given 80 mg qd . Blood pressure drops did not meet the effective standard, the drug dose doubled. The treatment time is 8 weeks. RESULTS: After 8 weeks, the blood pressure of the experimental group decreased from (148.8 ± 6.2) / (98.6 ± 2.2) mmHg to (126.5 ± 3.8) / (81.7 ± 2.2) mmHg, while the control group decreased from (147.5 ± 2.9) / (99.2 ± 2.6) ) mmHg decreased to (125.7 ± 4.9) / (80.9 ± 2.0) mmHg respectively, both groups were significantly lower than before treatment (P <0.01), the total effective rate of the experimental group and the control group were 86.9% and 88.8% > 0.05). No significant changes in heart rate in both groups, no significant adverse reactions during treatment. Conclusion: Domestic valsartan and imported valsartan have similar antihypertensive effects on mild to moderate essential hypertension without affecting heart rate with less adverse reactions.