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目的探讨新疆地区维吾尔族女性乳腺癌的发病特点、临床与病理特征及其与预后的关系。方法对74例有完整病例资料及随访的维吾尔族女性乳腺癌患者的临床病理资料进行多因素COX回归分析。结果74例维吾尔族女性乳腺癌3年生存率和5年生存率分别为75.00%(48/64)和43.50%(2/046),经多因素COX回归分析显示,年龄、月经状况、淋巴结转移、TNM分期及PR表达5项指标反应维吾尔族女性乳腺癌的预后情况,危险度分别为0.037,0.103,13.851,18.877和0.046。结论新疆维吾尔族女性乳腺癌患病的比重小,但发病年龄较早,以36～50岁多见,且以Ⅱ,Ⅲ期居多,预后较差。年龄、月经状况、淋巴结转移、TNM分期、PR表达是影响维吾尔族女性乳腺癌预后的独立指标。早诊断、早治疗是提高其生存率的关键。
Objective To investigate the incidence, clinical and pathological features of Uygur women with breast cancer in Xinjiang and their relationship with prognosis. Methods The clinical and pathological data of 74 cases of Uighur female breast cancer with complete case information and follow-up were analyzed by multivariate Cox regression. Results The 3-year survival rate and 5-year survival rate of 74 Uygur women with breast cancer were 75.00% (48/64) and 43.50% (2/046) respectively. Multivariate COX regression analysis showed that age, menstrual status, lymph node metastasis , TNM stage and PR expression of five indicators of Uygur women’s breast cancer prognosis, the risk were 0.037,0.103,13.851,18.877 and 0.046. Conclusion The prevalence of breast cancer in Uyghur women in Xinjiang is relatively low, but the age of onset is earlier than that of women aged 36-50 years. Most of them are in stage Ⅱ and Ⅲ, and the prognosis is poor. Age, menstrual status, lymph node metastasis, TNM stage and PR expression are independent prognostic factors in female Uighur women. Early diagnosis, early treatment is to improve the survival rate of the key.