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目的 观察进展期胃癌间质反应的分布特点 ,研究其意义。方法 收集近 3年来进展期胃癌手术切除标本 110例及较完整的临床资料 ,标本进行病理切片 ,HE染色 ,显微镜下观察、统计、分析。结果 110例胃癌间质中可见不同程度的淋巴细胞浸润 ,64 .5 5 %～ 77.2 8%胃癌间质有浆细胞浸润 ;5 7.2 7%～ 78%胃癌间质有嗜酸性粒细胞浸润 ;5 2 .75 %胃癌间质见红细胞 ;3 1.81%胃癌间质伴有明显的纤维组织增生。前三种浸润的细胞主要分布于胃癌旁间质 ,其次为癌巢之间间质及癌外胃壁各层 ,癌实质内很少见。分化型胃癌淋巴细胞浸润程度比低分化型的淋巴细胞浸润程度明显 ,差异非常显著(P <0 .0 1)。淋巴细胞浸润程度明显组与少量浸润组相比 ,胃癌伴淋巴结转移率低 ,P <0 .0 1(分别为3 2 .0 5 %和 64 % ,差异非常显著 )。结论 胃癌间质的各种反应与抗肿瘤的免疫反应有关
Objective To observe the characteristics of the distribution of interstitial reactions in advanced gastric cancer and study its significance. Methods The clinical data of 110 patients with advanced gastric cancer undergoing surgical resection in recent 3 years were collected and the complete clinical data were collected. The specimens were pathologically sectioned, stained with HE, and observed, statistically analyzed by microscopy. Results Lymphocyte infiltration was observed in 110 cases of gastric carcinoma, 64.55% to 77.2% of gastric carcinomas had plasma cell infiltration, 57.27% to 78% of gastric carcinomas had eosinophil infiltration; 5 2.75% of gastric cancers had interstitial erythrocytes; 3 1.81% of gastric carcinomas had significant fibrous tissue hyperplasia. The first three types of infiltrating cells are mainly located in the parasatellites of gastric cancer, followed by the interstitial space between the cancer nests and the outer layers of the stomach, and are rare in the cancer parenchyma. The degree of lymphocyte infiltration in differentiated gastric cancer was significantly higher than that in poorly differentiated lymphocytes (P < 0.01). Compared with the small infiltration group, the lymph node infiltration was significantly lower in the gastric cancer with lymph node metastasis (P < 0.01) (32.5% and 64%, respectively, with very significant difference). Conclusion The various responses of gastric cancer mesenchyme are related to the anti-tumor immune response