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目的观察胰岛素泵(CSⅡ)强化治疗2型糖尿病的临床疗效和不良反应。方法 60例2型糖尿病患者随机分为CSⅡ组和多次皮下注射胰岛素(MDI)组,观察两组患者的血糖、胰岛素用量、血糖达标时间、低血糖发生率及胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(IAI)的变化。结果 CSⅡ组的胰岛素用量、HOMA-IR、血糖、低血糖发生率、血糖达标时间明显比MDI组降低,P<0.05,但IAI明显增加,P<0.05。结论 CSⅡ强化治疗2型糖尿病临床疗效好于MDI。
Objective To observe the clinical effects and adverse reactions of insulin pump (CS Ⅱ) intensive treatment of type 2 diabetes mellitus (T2DM). Methods Sixty patients with type 2 diabetes mellitus were randomly divided into two groups: CS Ⅱ group and subcutaneous injection of insulin (MDI) group. The blood glucose, insulin dosage, blood glucose level, the incidence of hypoglycemia and insulin resistance index (HOMA-IR) , Insulin sensitivity index (IAI) changes. Results The dosage of insulin, HOMA-IR, blood sugar, incidence of hypoglycemia and blood glucose in CS Ⅱ group were significantly lower than those in MDI group (P <0.05), but IAI increased significantly (P <0.05). Conclusion CS Ⅱ intensive treatment of type 2 diabetes clinical efficacy is better than MDI.