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目的:评价加替沙星静滴、加替沙星静滴和左氧氟沙星口服序贯治疗下呼吸道感染的疗效和安全性。方法:将256例下呼吸道感染患者随机分为2组,其中对照组应用加替沙星注射液400 mg静滴,qd;序贯组用加替沙星注射液400 mg静滴qd,3 d后改为口服左氧氟沙星片400 mg,qd,疗程均为7～14 d。结果:对照组和序贯组总有效率分别为89.84%与85.94%,细菌清除率分别为95.33%与92.45%,药物不良反应发生率分别为8.59%与7.81%,其结果均无经统计学差异(P>0.05)。结论:加替沙星、左氧氟沙星序贯治疗下呼吸道感染具有与单用加替沙星静滴相似的临床疗效,但比单用依从性好。
Objective: To evaluate the efficacy and safety of gatifloxacin intravenous infusion, gatifloxacin intravenous infusion and levofloxacin oral sequential treatment of lower respiratory tract infection. Methods: 256 patients with lower respiratory tract infection were randomly divided into two groups. The control group received gatifloxacin 400 mg intravenously, qd, and the sequential group received gatifloxacin 400 mg intravenously qd for 3 days After the change to oral levofloxacin tablets 400 mg, qd, treatment were 7 to 14 days. Results: The total effective rates of the control group and the sequential group were 89.84% and 85.94% respectively, the bacterial clearance rates were 95.33% and 92.45% respectively, and the rates of adverse drug reactions were 8.59% and 7.81% respectively. The results were not statistically Difference (P> 0.05). Conclusion: Gatifloxacin and levofloxacin sequential treatment of lower respiratory tract infection with gatifloxacin intravenous infusion of similar clinical efficacy, but better than the single use of compliance.