论文部分内容阅读
目的利用Meta分析的方法探讨文献报道的中国已婚妇女宫颈癌发病相关因素。方法依据询证医学要求对相关医学数据库进行全面检索,将已婚妇女宫颈癌的病例对照研究筛选出来,对纳入研究的质量进行评价,然后对其进行Meta分析。结果宫颈癌发病的危险因素的合并OR值及其95%CI为:首次性交年龄1.91[1.23,2.97]、首次怀孕年龄2.90[1.33,6.30]、结婚次数4.34[2.18,8.64]、孕次2.40[1.26,4.56]、HPV25.49[4.23,153.75]、经济收入5.88[0.23,147.64]、初潮年龄10.52[0.56,196.54]、肿瘤家族史5.06[2.70,9.51]及吸烟2.36[1.64,3.37]。结论综合研究发现,首次性交年龄、首次怀孕年龄、结婚次数、孕次、HPV、经济收入、初潮年龄、肿瘤家族史及吸烟均为宫颈癌发病相关影响因素。
Objective To explore the related factors of cervical cancer incidence in Chinese married women reported in the literature by means of Meta analysis. Methods A comprehensive medical database was searched according to the requirements of medical inquiry. The case-control study of cervical cancer in married women was screened out, the quality of the included study was evaluated, and then Meta-analysis was carried out. Results The combined odds ratio (OR) and 95% CI of risk factors for cervical cancer were 1.91 [1.23,2.97] for the first intercourse, 2.90 [1.33,6.30] for the first pregnancy, 4.34 [2.18,8.64] for marriage, 2.40 [1.26,4.56], HPV25.49 [4.23,153.75], economic income 5.88 [0.23,147.64], menarche age 10.52 [0.56,196.54], family history of cancer 5.06 [2.70,9.51] and smoking 2.36 [1.64,3.37] . Conclusion Comprehensive study found that the first sexual intercourse age, the first pregnancy, the number of marriages, pregnancy times, HPV, economic income, age at menarche, family history of cancer and smoking are all the factors that influence the incidence of cervical cancer.