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本研究运用比色法测定临床各型慢性肝病血清Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶（β－ＮＡＧ）活性。同时检测患者肝纤维化其它指标如Ⅲ型前胶原肽（ＰⅢＰ）、Ⅳ型胶原，结合组织病理学变化，探讨β－ＮＡＧ在肝纤维化发生、发展中的意义。结果发现β—ＮＡＧ在肝纤维化早期就有显著升高，以慢性肝炎活动状态变化最明显，与ＣＩ－Ⅳ、ＰⅢＰ和血清白蛋白、白／球比明显相关，而ＣＩ－Ⅳ、ＰⅢＰ与ＡＬＴ、ＴＢ等肝功能指标相关性不明显。免疫组化显示肝纤维化时Ⅰ、Ⅲ型胶原增多明显，Ⅳ型胶原相对较少。提示β－ＮＡＧ在肝纤维化胶原降解中起重要作用，β－ＮＡＧ是诊断早期肝纤维化的敏感指标
In this study, the serum levels of N-acetyl-β-D-glucosaminidase (β-NAG) in various types of chronic liver disease were measured by colorimetry. At the same time, other indicators of liver fibrosis in patients with type Ⅲ procollagen peptide (P Ⅲ P), type Ⅳ collagen, combined with histopathological changes, explore the significance of β-NAG in the occurrence and development of liver fibrosis. The results showed that β-NAG was significantly increased in the early stage of liver fibrosis, with the most obvious changes in chronic hepatitis activity status, significantly correlated with CI-Ⅳ, PⅢP and serum albumin, white / ALT, TB and other indicators of liver function is not obvious. Immunohistochemistry showed that type Ⅰ and type Ⅲ collagen increased obviously and type Ⅳ collagen was relatively less in liver fibrosis. It is suggested that β-NAG plays an important role in the degradation of hepatic fibrosis collagen. Β-NAG is a sensitive indicator of early liver fibrosis