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目的:分析淋巴细胞亚群检测在小儿哮喘诊断中的临床意义。方法:选取2018年1月至2019年10月徐州市儿童医院健康体检的小儿50名为健康对照组，哮喘小儿107例为病例观察组进行回顾性分析。病例观察组根据临床症状及病史问询结果分为急性发作组(共44例)和持续发作组(共63例)。分析3组小儿在T细胞亚群细胞(CD3n ＋、CD4n ＋、CD8n ＋、CD4n ＋/CD8n ＋)水平的差异。n 结果:3组小儿T淋巴细胞亚群CD3n ＋、CD4n ＋、CD4n ＋/CD8n ＋比较，急性发作组和持续发作组均低于健康对照组，且持续发作组低于急性发作组(n P值均<0.05)；3组小儿T淋巴细胞亚群CD8n ＋比较，急性发作组和持续发作组均高于健康对照组，且持续发作组高于急性发作组(n F＝7.019，n P值均<0.05)。n 结论:与健康小儿比较，哮喘小儿的T淋巴细胞亚群表达存在差异，且持续性哮喘小儿的T淋巴细胞亚群表达差异更为显著，淋巴细胞亚群检测在小儿哮喘诊断中有一定的临床意义，尤其在反复持续性小儿哮喘临床诊断中的效果更佳。“,”Objective:To analyze the clinical significance of lymphocyte subsets in the diagnosis of asthma in children.Methods:From January 2018 to October 2019, 50 children who underwent physical examination in Xuzhou Children′s Hospital were taken as healthy control group, and 107 children with asthma admitted to pediatrics department were taken as case observation group.Case observation group was divided into acute attack group (44 cases) and persistent attack group (63 cases) according to clinical symptoms and medical history.To observe the difference of T cell subsets (CD3n +, CD4n +, CD8n +, CD4n +/CD8n +) in healthy control group, acute attack group and persistent attack group.n Results:Compared with the healthy control group, CD3n +, CD4n +, CD4n +/CD8n +, the acute attack group and the persistent attack group were lower than those of the healthy control group, and the persistent attack group was lower than that of the acute attack group (all n P<0.05). Compared with CD8n + the three groups, the acute attack group and the persistent attack group were higher than the healthy control group, and the persistent attack group was higher than the acute attack group (n F=7.019, n P<0.05).n Conclusions:Compared with healthy children, the expression of T lymphocyte subsets in children with asthma is different, and the expression of T lymphocyte subsets in children with persistent asthma is more significant.Therefore, the detection of T lymphocyte subsets has certain clinical significance not only in the diagnosis of childhood asthma, but also in the diagnosis of repeated persistent childhood asthma.