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目的：探讨硬膜外阻滞与异丙酚或依托咪酯复合麻醉对血流动力学和肝血流及氧供的影响。方法：选用健康杂种犬２２只行胸段硬膜外阻滞后，随机分为两组，分别静脉注射异丙酚２５ｍｇ／ｋｇ（ｎ＝１２）或依托咪酯０４ｍｇ／ｋｇ（ｎ＝１０），监测１０分钟内体循环、肝动脉、门静脉血流动力学及肝脏氧供。结果：硬膜外阻滞后ＨＲ、ＭＡＰ、ＳＶＲ、门静脉血流和氧供下降；异丙酚诱导后ＨＲ、ＭＡＰ、ＳＶＲ降低，ＣＯ也于２～５分钟时下降；依托咪酯诱导后各参数无进一步明显变化。两组肝动脉血流和氧供始终维持稳定。结论：硬膜外阻滞后应用异丙酚诱导对血流动力学影响虽较依托咪酯强，但两组肝血流和氧供均能维持。
Objective: To investigate the effects of epidural anesthesia combined with propofol or etomidate anesthesia on hemodynamics and hepatic blood flow and oxygen supply. Methods: Twenty-two healthy dogs were randomly divided into two groups: propofol 25mg / kg (n = 12) or etomidate 04mg / kg (n = n = 10). Body circulation, hepatic artery, portal vein hemodynamics and hepatic oxygen supply were monitored within 10 minutes. Results: HR, MAP, SVR, portal blood flow and oxygen supply decreased after epidural block; HR, MAP and SVR decreased after propofol induction; CO also decreased at 2-5 minutes; No further significant changes in parameters. Both hepatic artery blood flow and oxygen supply remained stable at all times. CONCLUSION: Although the effect of propofol induction on hemodynamics after epidural block is stronger than that of etomidate, both hepatic blood flow and oxygen supply can be maintained.