根据文献和作者的经验估计40%以上继发性闭经的妇女有高催乳激素血症,而同时有闭经和乳溢者发病率更高。许多高催乳激素血症患者在颅骨和蝶鞍常规和多层面X光照片有垂体腺瘤的证据。过去对已知有垂体肿瘤而无症状或体征的病例常不予处理。由于手术方法的改进和选择性地切除肿瘤能使闭经、乳溢和不孕症康复已引起对早期诊断和治疗催乳激素分泌性垂体肿瘤增加兴趣。虽然近来此瘤的发病数增加是因诊断方法的改进,而其他因素尤其是口服含雌激素的避孕药亦起重要作用。作者们从1976年起开始对垂体肿瘤作了多学科综合研究,作者所在的临床研究中心已有42例妇女, Based on the literature and authors’ experience, it is estimated that more than 40% of women with secondary amenorrhea have hyperprolactinemia, while those with amenorrhea and galactorrhea have a higher incidence. Many patients with hyperprolactinemia have evidence of pituitary adenomas in both conventional and multifaceted radiographs of the skull and sella. In the past, cases with asymptomatic or physical signs of known pituitary tumors were often left untreated. Improvements in surgical methods and the selective removal of tumors have enabled rehabilitation of amenorrhea, galactorrhea, and infertility to have caused increased interest in the early diagnosis and treatment of prolactin secretory pituitary tumors. Although the recent increase in the incidence of this tumor is due to improvements in diagnostic methods, other factors, especially oral contraceptives containing estrogen, also play an important role. The authors have conducted multidisciplinary comprehensive studies on pituitary tumors since 1976. The author’s clinical research center has 42 women.